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Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

Genes upregulated by GSTO1 siRNA showed significant enrichment of amino-acid deprivation response-related gene sets 29

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A oligomers are considered the most neurotoxic species in AD since the levels correlate with the presence of synaptic loss and, in turn, cognitive symptoms, particularly during the earliest stages of the disease

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